Smart PEEK Modified by Self-Initiated Surface Graft Polymerization for Orthopedic Bearings

Authors

  • Masayuki Kyomoto, PhD
  • Toru Moro, MD, PhD
  • Shihori Yamane, MSc
  • Kenichi Watanabe, BS
  • Yoshio Takatori, MD, PhD
  • Sakae Tanaka, MD, PhD
  • Kazuhiko Ishihara, PhD

DOI:

https://doi.org/10.15438/rr.4.3.79

Abstract

Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties, chemical stability, and nonmagnetism. In the present study, we propose a novel self-initiated surface graft polymerization technique, using which we demonstrate the fabrication of a highly hydrophilic and biocompatible nanometer-scale layer on the surfaces of PEEK and carbon fiber-reinforced PEEK (CFR-PEEK) by the photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) without using any photoinitiators. The thus formed hydrophilic and smooth 100-nm-thick PMPC-grafted layer caused a significant reduction in the sliding friction of the bearing interface because the thin water film and hydrated PMPC layer acted as extremely efficient lubricants (so-called fluid-film lubrication or hydration lubrication). Fluid-film lubrication suppressed the direct contact of the counter-bearing surface with the PEEK substrate and thus reduced the frictional force. A PMPC-grafted layer is therefore expected to significantly increase bearing durability. Furthermore, the PMPC-grafted layer shows unique phenomena, e.g., it prevents damage of the metal counter surface regardless of the carbon fiber content of CFR-PEEK. Smart PEEK using the self-initiated surface graft polymerization of MPC should lead to development of novel orthopedic bearings.

Keywords: poly(ether-ether-ketone), 2-methacryloyloxyethyl phosphorylcholine, surface modification, photopolymerization, joint replacement, wear mechanism

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References

Bozic KJ, Kurtz SM, Lau E, Ong K, Vail TP, Berry DJ. The epidemiology of revision total hip arthroplasty in the United States. J Bone Joint Surg Am 2009;91(1):128–133.

Jacobs JJ, Roebuck KA, Archibeck M, Hallab NJ, Glant TT. Osteolysis: basic science. Clin Orthop Relat Res 2001;393:71–77.

Glant TT, Jacobs JJ, Molnar G, Shanbhag AS, Valyon M, Galante JO. Bone resorption activity of particulate-stimulated macrophages. J Bone Miner Res 1993;8(9):1071–1079.

Kyomoto M, Iwasaki Y, Moro T, Konno T, Miyaji F, Kawaguchi H, et al. High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine). Biomaterials 2007;28(20):3121–3130.

Kyomoto M, Moro T, Saiga K, Miyaji F, Kawaguchi H, Takatori Y, et al. Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. Biomaterials 2010;31(4):658–668.

Kyomoto M, Ishihara K. Self-initiated surface graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on poly(ether-ether-ketone) by photo-irradiation. ACS Appl Mater Interfaces 2009;1(3):537–542.

Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Nakamura K, Ishihara K. Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone). Biomaterials 2010;31(6):1017–1024.

Kyomoto M, Moro T, Yamane S, Hashimoto M, Takatori Y, Ishihara K. Poly(ether-ether-ketone) orthopedic bearing surface modified by self-initiated surface grafting of poly(2-methacryloyloxyethyl phosphorylcholine). Biomaterials 2013;34(32):7829–7839.

Kyomoto M, Moro T, Yamane S, Watanabe K, Hashimoto M, Takatori Y, et al. Poly(2-methacryloyloxyethyl phosphorylcholine) grafting and vitamin E blending for high wear resistance and oxidative stability of orthopedic bearings. Biomaterials 2014;35(25):6677–6686.

Chevalier J, Grandjean S, Kuntz M, Pezzotti G. On the kinetics and impact of tetragonal to monoclinic transformation in an alumina/zirconia composite for arthroplasty applications. Biomaterials 2009;30(29):5279–5282.

Kurtz SM, Devine JN. PEEK biomaterials in trauma, orthopedic, and spinal implants. Biomaterials 2007;28(32):4845–4869.

Kurtz SM, ed. PEEK Biomaterials Handbook. Oxford, UK: Elsevier; 2012.

Field RE, Rajakulendran K, Eswaramoorthy VK, Rushton N. Three-year prospective clinical and radiological results of a new flexible horseshoe acetabular cup. Hip Int 2012;22(6):598–606.

Pace N, Spurio S, Rizzato G. Clinical trial of a new CF-PEEK acetabular insert in hip arthroplasty. Hip Int 2004;14(2):132–133.

Pace N, Marinelli M, Spurio S. Technical and histologic analysis of a retrieved carbon fiber-reinforced poly-ether-ether-ketone composite alumina-bearing liner 28 months after implantation. J Arthroplasty 2008;23(1):151–155.

Moro T, Takatori Y, Ishihara K, Konno T, Takigawa Y, Matsushita T, et al. Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis. Nature Mater 2004;3(11):829–837.

Moro T, Takatori Y, Kyomoto M, Ishihara K, Hashimoto M, Ito H, et al. Long-term hip simulator testing of the artificial hip joint bearing surface grafted with biocompatible phospholipid polymer. J Orthop Res 2014;32(3):369–376.

Iwasaki Y, Ishihara K. Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces. Sci Technol Adv Mater. 2012;13:064101 (14pp).

Saito S, Yamazaki K, Nishinaka T, Ichihara Y, Ono M, Kyo S, et al. Post-approval study of a highly pulsed, low-shear-rate, continuous-flow, left ventricular assist device, EVAHEART: a Japanese multicenter study using J-MACS. J Heart Lung Transplant 2014;33(6):599–608.

Kyomoto M, Moro T, Konno T, Takadama H, Yamawaki N, Kawaguchi H, et al. Enhanced wear resistance of modified cross-linked polyethylene by grafting with poly(2-methacryloyloxyethyl phosphorylcholine). J Biomed Mater Res A 2007;82(1):10–17.

Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Ishihara K. Cartilage-mimicking, high-density brush structure improves wear resistance of crosslinked polyethylene: a pilot study. Clin Orthop Relat Res 2011;469(8):2327–2336.

Takatori Y, Moro T, Kamogawa M, Oda H, Morimoto S, Umeyama T, et al. Poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liner in primary total hip replacement: one-year results of a prospective cohort study. J Artif Organs 2013;16(2):170–175.

Takatori Y, Moro T, Ishihara K, Kamogawa M, Oda H, Umeyama T, et al. Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners: Three-year results of a prospective consecutive series. Mod Rheumatol 2014, available under “Early online” (PMID: 25109744), DOI: 10.3109/14397595.2014.941438.

Kuiper KK, Nordrehaug JE. Early mobilization after protamine reversal of heparin following implantation of phosphorylcholine-coated stents in totally occluded coronary arteries. Am J Cardiol 2000;85(6):698–702.

Selan L, Palma S, Scoarughi GL, Papa R, Veeh R, Di Clemente D, et al. Phosphorylcholine impairs susceptibility to biofilm formation of hydrogel contact lenses. Am J Ophthalmol 2009;147(1):134–139.

Wang A, Lin R, Stark C, Dumbleton JH. Suitability and limitations of carbon fiber reinforced PEEK composites as bearing surfaces for total joint replacements. Wear 1999;225–229(2):724–727.

Wang A, Lin R, Polineni VK, Essner A, Stark C, Dumbleton JH. Carbon fiber reinforced polyether ether ketone composite as a bearing surface for total hip replacement. Tribol Int 1998;31(11):661–667.

Scholes SC, Inman IA, Unsworth A, Jones E. Tribological assessment of a flexible carbon-fibre-reinforced poly(ether-ether-ketone) acetabular cup articulating against an alumina femoral head. Proc Inst Mech Eng H. 2008;222(3):273–283.

Wang QQ, Wu JJ, Unsworth A, Briscoe A, Jarman-Smith M, Lowry C, et al. Biotribological study of large diameter ceramic-on-CFR-PEEK hip joint including fluid uptake, wear and frictional heating. J Mater Sci Mater Med 2012;23(6):1533–1542.

Brockett CL, John G, Williams S, Jin Z, Isaac GH, Fisher J. Wear of ceramic-on-carbon fiber-reinforced poly-ether ether ketone hip replacements. J Biomed Mater Res B Appl Biomater 2012;100(6):1459–1465.

Bhosale AM, Richardson JB. Articular cartilage: structure, injuries and review of management. Br Med Bull 2008;87:77–95.

Kyomoto M, Moro T, Saiga K, Hashimoto M, Ito H, Kawaguchi H, et al. Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials. Biomaterials 2012;33(18):4451–4459.

Evans A, Horton H, Unsworth A, Briscoe A. The influence of nominal stress on wear factors of carbon fibre-reinforced polyetheretherketone (PEEK-OPTIMA® Wear Performance) against zirconia toughened alumina (Biolox® delta ceramic). Proc Inst Mech Eng H 2014;228(6):587–592.

Levine BR, Hsu AR, Skipor AK, Hallab NJ, Paprosky WG, Galante JO, et al. Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*. J Bone Joint Surg Am 2013;95(6):512–518.

Utzschneider S, Becker F, Grupp TM, Sievers B, Paulus A, Gottschalk O, et al. Inflammatory response against different carbon fiber-reinforced PEEK wear particles compared with UHMWPE in vivo. Acta Biomater 2010;6(11):4296-4304. Erratum in: Acta Biomater 2012;8(3):1396–1398.

Howling GI, Sakoda H, Antonarulrajah A, Marrs H, Stewart TD, Appleyard S, et al. Biological response to wear debris generated in carbon based composites as potential bearing surfaces for artificial hip joints. J Biomed Mater Res B Appl Biomater 2003;67(2):758–764.

Lorber V, Paulus AC, Buschmann A, Schmitt B, Grupp TM, Jansson V, et al. Elevated cytokine expression of different PEEK wear particles compared to UHMWPE in vivo. J Mater Sci Mater Med 2014;25(1):141–149.

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Published

2014-10-01

How to Cite

Kyomoto, PhD, M., Moro, MD, PhD, T., Yamane, MSc, S., Watanabe, BS, K., Takatori, MD, PhD, Y., Tanaka, MD, PhD, S., & Ishihara, PhD, K. (2014). Smart PEEK Modified by Self-Initiated Surface Graft Polymerization for Orthopedic Bearings. Reconstructive Review, 4(3). https://doi.org/10.15438/rr.4.3.79

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